Allopregnanolone
Clinical teaching and practical ideas for your next study session.
Case Discussion
Why PMDD SSRIs Can Work in Days: The Allopregnanolone Hypothesis
An illustrative patient with a prospectively charted cyclic pattern reports improvement after several days of an SSRI. Learn why rapid benefit is plausible in PMDD, what the allopregnanolone–GABA-A model proposes, and why neither the model nor early response establishes a diagnosis or mechanism.