PMDD
Clinical teaching and practical ideas for your next study session.
Case Discussion
Why PMDD SSRIs Can Work in Days: The Allopregnanolone Hypothesis
An illustrative patient with a prospectively charted cyclic pattern reports improvement after several days of an SSRI. Learn why rapid benefit is plausible in PMDD, what the allopregnanolone–GABA-A model proposes, and why neither the model nor early response establishes a diagnosis or mechanism.
Medical Education
Before PMDD Surgery: What a GnRH Agonist Trial Can Tell You
For severe, treatment-resistant PMDD, a GnRH agonist trial can inform decisions about irreversible ovarian surgery. Learn what improvement, nonresponse, and add-back effects do—and do not—mean.